L-arginine in norm and pathology

Author: L.K. Sokolova, V.M. Pushkarev, M.D. Tronko
Published: ENDOKRYNOLOGIA’ 2019, VOLUME 24, No. 4

L-arginine in norm and pathology

Abstract. L-arginine is a conditionally essential amino acid, which is the cellular regulator of many vital functions of the body. He is involved in the regulation of the tone of the smooth muscle component of the blood vessels wall, bronchi, and intestines. L-arginine is a substrate for the nitric oxide synthase (NOS), which produces nitric oxide (NO). NO, produced in the vascular endothelium of endothelial NOS, is responsible for the relaxation of smooth muscles and is necessary to lower blood pressure. L-arginine has a high functional priority in the production of NO and, therefore, in the physiology of the cardiovascular and cerebrovascular systems. L-arginine can reduce obesity, lower blood pressure, suppress oxidative processes and normalize endothelial dysfunction, contributing to remission in type 2 diabetes. L-arginine is also used by cells of the immune system, can reduce the level of infection, especially in case of impaired immune function. L-arginine slows down aging, inhibits platelet aggregation, and regulates multiple metabolic pathways associated with the metabolism of fatty acids, glucose, amino acids and proteins. Therefore, one should take into account the great therapeutic potential of L-arginine and continue to study the possibilities of its use as a promising drug against the progression of vascular dysfunction associated with aging, diabetes and cardiovascular diseases.

Keywords: L-arginine, nitric oxide, diabetes, cardiovascular system, obesity, cerebrovascular system, immune system, platelet aggregation.

Last Publication:

School of endocrinologist: some aspects of infusion treatment of diabetes

The principles of the educational project “School of Endocrinologist”, which has become traditional, include the originality of the submission of theoretical material, its practical orientation and interactive communication. In accordance with these principles, the latest recommendations, current views on some pathological conditions and methods of their treatment were presented to the participants.